Dr. Yang has published 40 papers in prestigious medical journals:

1. Yang, K. and Wang, Y.: Hormone receptors and human diseases.J. of World Medicine, 1:57-68, 1984.

2. Yang, K., Yang, C., Jiang, Y., Shen, W. and Qiou, L.: Analysis of masticatory muscles coordination
activities in TMJ dysfunction. J. of Shanghai Stomatology, 1:78-84,1986.

3. Yang, K., Bai, Y., Yang, C., Jiang, Y., Shen, W. and Qiou, L.: Microcomputer-aided masticatory
muscles EMG process system. Proceeding of Computer Application in Biomedical Sciences, Shanghai,
October 1986.

4. Shen, W., Yang, C., Jiang, Y., Yang, K., and  Qiou, L.: The variation of taste sensitivity in aged
people. Proceeding of Stomatology Diseases in Aged People, Wuhan, June 1986.

5. Diaz-Chico, J.B., Yang, K.G., Yang, K.Y., Efremov, D.G., Stoming, T.A. and Huisman, T.H.: The
detection of beta-globin gene mutation in beta-thalassemia using oligonucleotide process and
amplified DNA. Biochemica et Biophysica Acta, 949(1):43-48, 1988.

6. Taft, W.C., Yang, K., Dixon, C.E. and Hayes, R.L.: Microtubule-associated protein 2 (MAP2) levels
decrease in hippocampus following traumatic brain injury. J. of Neurotrauma, 9(3):281-290, 1992.

7. Todaro C., Yang, K., Iacopino, D.G., Cardia, E. and Tomasello, F.: Transcranial doppler sonography in
neonates with hydrocephalus. Acta Polytechnica, 33(2):123-126, 1993.

8. Taft, W.C., Yang, K., Dixon, C.E., Clifton, G.L. and Hayes, R.L.: Hypothermia attenuates the loss of
hippocampal microtubule-associated protein 2 (MAP2) levels following traumatic brain injury. J.
Cereb. Blood Flow Metab. 12:817-822, 1993.

9. Yang, K., Taft, W.C., Dixon, C.E., Todaro, C.A., Yu, R.K. and Hayes, R.L.: Alterations of protein kinase
C in rat hippocampus following traumatic brain injury. J. Neurotrauma, 10(3):287-295, 1993.

10. Yang, K., Taft, W.C., Dixon, C.E., Yu, R.K., Hayes, R.L.: Endogenous phosphorylation of a 61,000
dalton hippocampal protein increases following traumatic brain injury. J Neurotrauma 11(5):523-532,
1994.

11. Yang, K., Liu, P.K., Whitson, J., Mu, S., Xue, J.J., Antero, S., Dixon, C.E., Hsu, C.Y., Hayes, R.L.:
Increased expression of c-fos gene and AP-1 transcription factor after cortical impact injury in
rodents.  Brain Research 664:141-147, 1994.

12. Yang, K., Faustinella, F., Xue, J.J., Whitson, J.S., Kampfl, A., Mu, S., Zhao, X., Taglialatela, G., Perez-
Polo, R., Clifton, G.L., Hayes, R.L.:  Optimizing liposome-mediated gene transfer in primary rat septo-
hippocampal cell cultures.  Neuroscience Letters 182:287-290, 1994.

13. Yang, K., Faustinella, F., Xue, J.J., Whitson, J.S., Kampfl, A., Mu, S., Zhao, X., Taglialatela, G., Perez-
Polo, R., Clifton, G.L., Hayes, R.L.:  Sustained expression of functional nerve growth factor in
primary septo-hippocampal cell cultures by liposome-mediated gene transfer.  Neuroscience Letters
182:291-294, 1994.

14. Hayes, R.L., Yang, K., Whitson, J.S., Xue, J.J., Kampfl, A., Mu, X.S., Zhao, X., Faustinella, F., Clifton,
G.L.:  Rescue of injury-induced neurofilament loss by BDNF gene transfection in primary septo-
hippocampal cell cultures. Neuroscience Letters 191:121-125, 1995.

15. Hayes, R.L., Yang, K., Raghupathy, R., McIntosh, T.K.:  Changes in gene expression following
traumatic brain injury in the rat. J Neurotrauma, 12(5):779-790, 1995.

16. Hayes, R.L., Yang, K., Whitson, J.S., Posmantur, R.:  Cytoskeletal derangements following central
nervous system injury: modulation by neurotrophic gene transfection.  J. Neurotrauma, 12(5): 933-  
942.

17. Yang, K., Mu, X.S., Hayes, R.L.: Increased cortical nuclear factor-kappa B (NF-kappa B) DNA binding
activity after traumatic brain injury in rats. Neuroscience Letters 197 (2):101-104, 1995.

18. Dixon, C.E., Bao, J., Johnson, K.M., Yang, K., Whitson, J.S., Clifton, G.L., Hayes, R.L.:   Basal and
scopolamine-evoked release of hippocampal acetylcholine following traumatic brain injury.  
Neuroscience Letters 198 (2): 111-114, 1995.

19. Dixon, C.E., Liu, S.J., Jenkins, L.W., Bhattachargee, M., Whitson, J.S., Yang, K., Hayes, R.L.:  Time
course of increased vulnerability of cholinergic neurotransmission following traumatic brain injury in
the rat. Behavioral Brain Research, 70: 125-131, 1995.

20. Kampfl, A., Zhao, X., Whitson, J.S., Posmantur, R., Dixon, C.E., Yang, K., Clifton, G.L., Hayes, R.L.:
Calpain inhibitors protect against depolarization induced neurofilament protein loss of septo-
hippocampal neurons in culture. Eur J Neuroscience, 8: 344-352, 1996.

21. Yang, K., Xue, J.J., Mu, X.S., Perez-Polo, J.R., Hayes, R.L.:  Regional and temporal profiles of c-fos
and NGF mRNA expression in rat brain after lateral cortical impact injury in rats.  J. Neuroscience
Research, 42: 571-578, 1995.

22. Yang, K., Perez-Polo, R., Mu, X., Yan, H., Xue, J.J., Iwamoto, Y., Liu, S.J., Dixon, C.E., Hayes, R.L.:  
Increased expression of BDNF but not NT-3 mRNA in rat brain after cortical impact injury.  J.
Neurosci. Res. 44:157-164, 1996.

23. Le, W., Yang, K., Whitson, J., Clifton, G.L., and Hayes, R.L.:Liposome-mediated NGF gene
transfection increases ChAT activity in rat septo-hippocampal cell cultures. NeuroReport, 7: 710-
712, 1996.  

24. Iwamoto, Y., Yang. K., Mu, X.S., Xue, J.J., Clifton, G.L., and Hayes, R.L.:BDNF cDNA following
liposome-mediated gene transfer in intact and traumatically injured rat brain.  Neuroreport, 7:609-
612, 1996.

25. Yang, K., Xue, J.J., Whitson, J.S., Kampfl, A., Zhao, X., Iwamoto, Y., Mu, X.S., Faustinella, F.,
Clifton, G.L., Hayes, R.L.:  Liposome-mediated NGF gene transfection increases phosphorylated
neurofilament proteins.  Molecular Brain Research, 43:13-20, 1996.

26. Yang, K., Clifton, G.L., and Hayes, R.L.:  Gene therapy for traumatic brain injury review.  J
Neurotrauma, 14 (5): 281-297, 1997.

27. Yang, K., Mu, X.S., Hayes, R.L., Huang, L., Clifton, G.L.: DC-Chol liposome-mediated gene
transfection in rodent spinal cord. NeuroReport, 8:9-10:5306, 1997.        

28. Qiu, Y.H., Hayes, R.L., Zhao, X., Pike, B.R., Clifton, G.L., Yang, K.: Activation of phosphatidylinositol 3
kinase by BDNF gene transfection in septo hippocampal cultures. J. Neurosci. Res. 52:192 200,
1998.

29. Zou, L. L., Huang, L., Hayes, R., Black, C., Qiu, Y.H., Perez Polo, J.R., Le, W., Clifton, C.L.  and Yang,
K.: Liposome mediated NGF gene transfection following neuronal injury: potential therapeutic
applications. Gene Therapy 6:994-1005, 1999.

30. Jeschke M. G., Barrow R.E., Hawkins, H.K., Yang, K., Perez Polo, R.J., Hayes, R., Lichtenbelt, M.S.
and Merndon, D.N: IGF I gene transfer in thermal injury. Gene Therapy 6:1015-1020, 1999.

31. Zou, L., Zhou, H., Pastore, L., Yang, K.: Prolonged transgene expression mediated by a helper-
dependent adenoviral vector in the central nervous system. Molecular Therapy 2 (2):105-113, 2000.

32. Hornsby,  P.J., Ozol, K., and Yang K.:Adrenocortical cells immortalized by telomerase: Potential use
for ex vivo gene therapy. Journal of Anti-Aging  Medicine 2000.

33. Zou, L.L., Yuan, X., Zhou, H., Lu, H., Yang, K.: Helper-Dependent Adenoviral Vector (hdAdv)-
Mediated Gene Transfer in Aged Rat Brain. Human Gene Therapy 12:181-191, 2001.

34. Kumar, A.., Zou, L.,  Yuan, X., Long, Y., Yang, K.: NMDA receptors: transient loss of nr1/nr2a/nr2b
subunits after traumatic brain injury in a rodent model. J Neuroscience Research, 67:781-786, 2002.

35. Zou, L.L., Yotnda, P., Zhao, T., Yuan, X., Kumar, A., Zhou, H., Brenner, M., Yang, K.: Reduced
Inflammatory Reactions to the Inoculation of Helper-Dependent Adenoviral Vectors in Traumatically
Injured Rat Brain. J of Cerebral Blood Flow and Metabolism 22: 959-970, 2002.

36. Zou, L.,  Yuan, X., Long, Y., Kmar, A., Shine, D., Yang, K.: Improvement of Spatial Learning and
Memory after Adenovirus-Mediated Transfer of Nerve Growth Factor Gene to Aged Rat Brain. Human
Gene Therapy. 13:2173-2184, 2002.

37. Long, Y.,  Zou, L.L., Liu, H., Lu, H., Yuan, X.Q., Robertson, C., and Yang, K.: Altered Expression of
Randomly Selected Genes in Mouse Hippocampus After Traumatic Brain Injury. J Neuroscience
Research 71:710-720, 2003.

38. Chen Q, He Y, Yang K. (2005) Gene Therapy for Parkinson’s Disease: Progress and Challenges. Curr
Gene Ther. 5:71-80.

39. Chen Q, Long Y, Yuan XQ, Zou LL, Sun J, Chen SD, Perez-Polo R, Yang K. (2005) Protective Effects
of Bone Marrow Stromal Cell Transplantation in Injured Rodent Brain: Synthesis of the Neurtrophic
factors. Journal of Neuroscience Research. 80:611-619.

40. Chen Q, He Y, Yuan XQ, P Ng, Chen SD and Yang K. (2006) Helper-Dependent Adenovirus Mediated
Gene Therapy for the Central Nervous System. Chinese Journal of Neuromedicine.


Invited Book Chapters and Reviews:

1. Yang, K.: Intracellular changes in signal transduction, transcription factors, immediate early genes and
gene transfection. International Business Communications: Head Trauma. IBC BioMedical Library
Series,  Philadelphia, PA, 1996

2. Yang, K., Perez-Polo, J.R., Faustinella, F., Taglialatela, G., Hayes, R.L.:  In vitro studies of liposome-
mediated gene transfection. In: Paradigms in Neural Injury. J.R. Perez-Polo, (Ed.)  Academic Press
Inc., San Diego, CA  pp. 290-298, 1996.

3. Hayes, R.L., Yang, K.: Gene therapy for treatment of post-acute impairment following injury to the
central nervous system. In: Neuropsychological Rehabilitation, Carrion, J.L. (Ed.) GR Press, Orlando
Florida, 1997.        
Publications of Dr. Yang
MOUNT RAINIER
NEUROLOGY
Clinic and Diagnostic Center